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Advances in Connexin-Based Biomarkers and Therapeutics for Disease Diagnosis and Treatment

Advances in Connexin-Based Biomarkers and Therapeutics for Disease Diagnosis and Treatment

Connexin biology is a rapidly developing field that plays an important role in intercellular communication via gap junctions and hemichannels. These connexin-mediated pathways are essential for maintaining cellular homeostasis and have been associated with a variety of diseases, including cancer, congenital cataracts, depression, hereditary deafness, and congenital heart disease. Recent studies have highlighted the dual role of connexins, involving both channel-dependent and independent functions, which are crucial in disease pathogenesis. Despite progress, significant gaps remain in understanding the full spectrum of connexin functions and their potential as biomarkers for disease diagnosis and prognosis. Current research is focused on developing molecular approaches such as mimetic peptides, connexin inhibitors, and antibodies to effectively target these proteins. However, translation of these findings into clinical practice is still in its infancy and requires further research into the mechanisms and therapeutic potential of connexin targeting strategies.

This Research Topic aims to explore the latest advances in the development of connexin-based biomarkers and connexin targeting agents in clinical research settings. Primary goals include understanding the application of these biomarkers and agents in various disease contexts and elucidating their potential diagnostic and therapeutic implications. Key questions to be addressed include the effectiveness of connexin-targeting agents in preclinical and clinical studies, the molecular mechanisms underlying these agents, and the impact of connexin mutations on disease susceptibility and progression.

To gather more information in the field of Connexin biology and clinical applications, we welcome Brief Research Report, Clinical Investigation, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, and Systematic Review articles that address the following topics. but not limited to the following themes:

• Investigation of connexin-based biomarkers for disease diagnosis and prognosis.
• Evaluation of agents targeting Connexin in preclinical and clinical studies.
• Molecular mechanisms underlying connexin targeting agents.
• Impact of connexin mutations on disease susceptibility and progression.
• Development of new molecular strategies targeting connexins for therapeutic interventions.
• Connexin dysfunction in ocular diseases and potential therapeutic interventions.
• Connexin-based approaches for regenerative medicine and tissue engineering.


Keywords: Connexins, Diseases, Therapy, Diagnosis, Gap Junctions


Important Note: All contributions to this Research Topic must be within the scope of the department and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

Connexin biology is a rapidly developing field that plays an important role in intercellular communication via gap junctions and hemichannels. These connexin-mediated pathways are essential for maintaining cellular homeostasis and have been associated with a variety of diseases, including cancer, congenital cataracts, depression, hereditary deafness, and congenital heart disease. Recent studies have highlighted the dual role of connexins, involving both channel-dependent and independent functions, which are crucial in disease pathogenesis. Despite progress, significant gaps remain in understanding the full spectrum of connexin functions and their potential as biomarkers for disease diagnosis and prognosis. Current research is focused on developing molecular approaches such as mimetic peptides, connexin inhibitors, and antibodies to effectively target these proteins. However, translation of these findings into clinical practice is still in its infancy and requires further research into the mechanisms and therapeutic potential of connexin targeting strategies.

This Research Topic aims to explore the latest advances in the development of connexin-based biomarkers and connexin targeting agents in clinical research settings. Primary goals include understanding the application of these biomarkers and agents in various disease contexts and elucidating their potential diagnostic and therapeutic implications. Key questions to be addressed include the effectiveness of connexin-targeting agents in preclinical and clinical studies, the molecular mechanisms underlying these agents, and the impact of connexin mutations on disease susceptibility and progression.

To gather more information in the field of Connexin biology and clinical applications, we welcome Brief Research Report, Clinical Investigation, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, and Systematic Review articles that address the following topics. but not limited to the following themes:

• Investigation of connexin-based biomarkers for disease diagnosis and prognosis.
• Evaluation of agents targeting Connexin in preclinical and clinical studies.
• Molecular mechanisms underlying connexin targeting agents.
• Impact of connexin mutations on disease susceptibility and progression.
• Development of new molecular strategies targeting connexins for therapeutic interventions.
• Connexin dysfunction in ocular diseases and potential therapeutic interventions.
• Connexin-based approaches for regenerative medicine and tissue engineering.


Keywords: Connexins, Diseases, Therapy, Diagnosis, Gap Junctions


Important Note: All contributions to this Research Topic must be within the scope of the department and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.